منابع مشابه
Homocysteine and thiol metabolites in vitamin B12 deficiency.
Homocysteine metabolism is increasingly implicated in a diverse group of clinical disorders, including atheromatous vascular disease. We studied the disposition of homocysteine via the trans-sulphuration pathway, plasma glutathione peroxidase (GPx) activity and plasma levels of the sulphated hormone dehydro-epiandrosterone sulphate (DHEAS) in six vitamin B(12)-deficient human subjects before an...
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We describe a versatile high-performance liquid-chromatographic method for determining homocysteine and other plasma sulfhydryls. Using three different procedures for preparation of plasma, we determined total, free (non-protein-bound), and reduced forms of homocysteine, cysteine, glutathione, cysteinylglycine, and gamma-glutamylcysteine in human plasma. Sample preparation involves disulfide re...
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A profession that claims to understand economies, and that has gained power over the greater part of our societies, has big responsibilities. The fundamental responsibility is to ensure its perception of economies gives some useful guidance to the behaviour of real economies. Here mainstream economics fails utterly, and has been failing for a long time. Worse, it actively resists alternative vi...
متن کاملProtein Thiol Modification and Thiol Proteomics
Cysteine plays an important role in the regulation of redox chemistry and gene expression and is essential in the structural and macromolecular organisation of proteins. Thiol oxidation leads to misfolding and the influencing of the protein function (Buczek et al., 2007). In our experiments, we have identified an oxidised cytoskeletal protein actin involved in the rearrangement of filament in t...
متن کاملHomocysteine.
Homocysteine does not occur in the diet but it is an essential intermediate in normal mammalian metabolism of methionine. Each compound, methionine or homocysteine, is the precursor of the other. Similarly, the synthesis of one is the mechanism for the detoxification of the other. The ubiquitous methionine cycle is the metabolic basis for this relationship. In some tissues the transsulfuration ...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2005
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.20708